California Veterinary Specialists continues to work with medical industry partners to help create new therapies for the treatment of our companion animal family members. We have recently launched a Phase II double blind placebo controlled clinical trial targeting canine lipomas. The hypothesis is that an injection of Cl histolyticum purified collagenase (enzyme) will cause a rapid and durable reduction in size of canine lipomas. We are currently enrolling dogs with moderate sized lipomas as candidates. Inclusion criteria are tumors that are approximately 2-6 centimeters in diameter with essentially healthy dogs. The study is non-invasive and requires three to four follow-up visits. Results from a dose escalation and Phase I trial indicate very positive results with more that 90% of the patients achieving a reduction in lipoma size of at least 50% with a single injection. Side effects noted in these studies were trivial; the drug is FDA approved for use in humans with over 11,000 people already having been injected with the drug to date. Interested candidates can be enrolled by contacting the study site coordinator Jannete at 760-448 9480.